HIRN 2025 Annual Meeting

The PI Roberto Mallone from our partner INSERM will be presenting at the Human Islet Research Network (HIRN) Annual Meeting from 13-14 January 2025. His presentation “The menage à trois between beta cells, T cells and interferons”

Type 1 Diabetes results from an interplay between autoimmune T cells and dysfunctional beta cells, favored by the inflammatory islet environment set up by interferons. The presentation will highlight some novel aspects of this interplay, notably the increased autoimmune visibility and vulnerability of beta cells driven by the preferential upregulation of HLA-B Class I molecules presenting conventional and neo-antigenic peptides.