ENT1DEP at Diabetes UK Professional Conference

Our partner PI, Dr. Roberto Mallone, will represent ENT1DEP at the Diabetes UK Professional Conference

Diabetes UK Professional Conference
📅 Date: February 26-28, 2025
📍 Location: Glasgow, UK
🔗 Event Link: https://www.diabetes.org.uk/diabetes-uk-professional-conference

    Presentation Title: “The ménage à trois between beta cells, T cells, and interferons”

    Key Highlights: T1D results from an interplay between autoimmune T cells and dysfunctional beta cells, favored by the inflammatory islet environment set up by interferons. We will highlight some novel aspects of this interplay, notably the increased autoimmune visibility and vulnerability of beta cells driven by the preferential upregulation of HLA-B Class I molecules presenting conventional and neo-antigenic peptides.

    Link: Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells.

    Stay tuned for more updates on our research and contributions to the field of Type 1 Diabetes.